The complete Khavinson family of short peptides — organ-specific bioregulators that modulate gene expression in targeted tissues, developed at the St. Petersburg Institute of Bioregulation and Gerontology.

Russian Bioregulator Peptides

The Khavinson bioregulators are a family of short peptides (2-4 amino acids) developed by Professor Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. These peptides are theorized to modulate gene expression in specific target tissues through direct interaction with DNA, and have been the subject of decades of Russian clinical and experimental research.

Complete Peptide Directory

Neuroactive Bioregulators

Peptide	Sequence	Target Tissue	Primary Research Focus
Cortagen	Ala-Glu-Asp-Pro	Brain cortex	Neuroprotection, cognitive function, cortical gene expression
Pinealon	Glu-Asp-Arg	Brain / Pineal	Pineal gland function, neuroprotection, circadian rhythm
Cortexin	Peptide complex	Brain cortex	Cognitive enhancement, stroke recovery, TBI, epilepsy
Retinalamin	Peptide complex	Retina	Retinal degeneration, diabetic retinopathy, macular degeneration
Cerluten	Short peptide	Brain	CNS gene expression modulation, cognitive support in aging

Immune & Thymic Bioregulators

Peptide	Sequence	Target Tissue	Primary Research Focus
Vladonix	Short peptide	Thymus	Thymic regeneration, immune restoration in elderly
Vilon	Lys-Glu	Thymus	Immune gene reactivation, thymic signaling
Thymalin	Peptide complex	Thymus	T-cell maturation, immunosenescence reversal
Livagen	Lys-Glu-Asp-Ala	Immune/Liver	Chromatin decondensation, immune gene reactivation
Kristagen	Tetrapeptide	Immune system	Immune cell gene expression, thymic peptide signaling
Revilab SL-01	Multi-peptide	Immune system	Combined bioregulator approach to immune restoration

Musculoskeletal Bioregulators

Peptide	Sequence	Target Tissue	Primary Research Focus
Sigumir	Short peptide	Cartilage/Bone	Joint health, osteoarthritis, cartilage regeneration
Cartalax	Ala-Glu-Asp	Cartilage/Skin	Anti-aging effects on cartilage and skin fibroblasts

Organ-Specific Bioregulators

Peptide	Sequence	Target Tissue	Primary Research Focus
Cardiogen	Ala-Glu-Asp-Arg	Heart	Myocardial regeneration, age-related cardiac decline
Ventfort	Lys-Glu-Asp	Blood vessels	Vascular elasticity, age-related vessel deterioration
Bronchogen	Ala-Glu-Asp-Leu	Lungs	Pulmonary epithelial repair, respiratory inflammation
Chonluten	Thr-Glu-Asp	Lungs/GI	Mucosal tissue gene expression, anti-inflammatory
Ovagen	Short peptide	Liver	Hepatic function, detoxification pathways
Svetinorm	Short peptide	Liver	Hepatoprotection, liver regeneration
Stamakort	Short peptide	Stomach	Gastric mucosa repair, digestive function
Bonomarlot	Short peptide	Bone marrow	Hematopoiesis, blood cell production
Prostamax	Short peptide	Prostate	Prostate health, age-related changes
Testagen	Short peptide	Testes	Testicular function, hormonal support
Taxorest	Short peptide	Lungs	Bronchial tissue repair, respiratory function
Endoluten	Short peptide	Pineal gland	Melatonin regulation, neuroendocrine signaling

Longevity Bioregulators

Peptide	Sequence	Target	Primary Research Focus
Epithalon	Ala-Glu-Asp-Gly	Pineal / Telomerase	Telomerase activation, lifespan extension in animal models
N-Acetyl Epithalon Amidate	Modified Epithalon	Pineal / Telomerase	Enhanced bioavailability version, telomere research
Epithalon Nasal	Epithalon formulation	Pineal / Telomerase	Intranasal delivery for improved CNS access

Short Peptide Sequences

Peptide	Sequence	Primary Research Focus
AEDP	Ala-Glu-Asp-Pro	Bioregulatory gene expression modulation
KEDW	Lys-Glu-Asp-Trp	Tissue-specific gene expression regulation
LKEK	Leu-Lys-Glu-Lys	General anti-aging, immune modulation
Lac-Leu	Lactyl-Leucine	Metabolic signaling and gene regulation
AF-DKPZGHY	Cyclic dipeptide complex	Bioregulatory signaling, gene expression
AF2121	Synthetic bioregulator	Tissue-specific gene modulation research
Tetra-Glycine	Gly-Gly-Gly-Gly	Minimal peptide bioregulatory research

Common Research Themes

Gene Expression Modulation: Khavinson's central thesis is that short peptides interact directly with specific DNA sequences, modulating gene expression in their target tissues without acting as traditional receptor agonists. This mechanism is supported by in vitro studies showing peptide-DNA binding.

Organ Specificity: Each bioregulator is proposed to have affinity for a specific tissue type. This organ-targeting specificity is the hallmark of the Khavinson approach and distinguishes it from other peptide therapy paradigms.

Geroprotective Research: Many bioregulators have been studied in elderly populations in Russian clinical settings, with reported improvements in organ function, mortality rates, and quality of life.

Combinatorial Protocols: Russian clinical protocols often combine multiple bioregulators targeting different organ systems simultaneously (e.g., Vladonix + Ventfort + Epithalon for comprehensive anti-aging). This combinatorial approach reflects the organ-specific nature of each peptide.

Getting Started

If you are new to this category, we recommend starting with Epithalon — the most internationally recognized bioregulator with telomerase-activating properties studied by Khavinson. From there, explore related peptides through the See Also sections on each page to build a comprehensive understanding of the research landscape.

Russian Bioregulator Peptides

On this page